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RI (dl) -2

RI (dl) -2 blocks RAD51’s D-loop activity in biochemical systems with an IC50 value of 11.1 µM and inhibits homologous recombination (HR) activity with an IC50 value of 3.0 µM. RI (dl) -2 inhibits HR-mediated repair of DNA double strand breaks and sensitizes different cancer cell lines[1].

Product Specifications

CAS Number

1902146-75-1

UNSPSC

12352005

Target

RAD51

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ri-dl-2.html

Solubility

10 mM in DMSO

Smiles

CCNC(C=C1)=CC=C1C2=NC3=C(N4C=CC=C42)C=CC=C3

Molecular Formula

C19H17N3

Molecular Weight

287.36

References & Citations

[1]Wei Lv, et al. Development of Small Molecules that Specifically Inhibit the D-loop Activity of RAD51. J Med Chem. 2016 May 26;59 (10) :4511-25.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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