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SPSB2-iNOS inhibitory cyclic peptide-2 (TFA)

SPSB2-iNOS inhibitory cyclic peptide-2 TFA is the TFA salt form of SPSB2-iNOS inhibitory cyclic peptide-2. SPSB2-iNOS inhibitory cyclic peptide-2 TFA is an inhibitor for the interaction of SPRY domain and SOCS-box protein 2 (SPSB2) and iNOS, through binding SPSB2 on iNOS site with KD of 21 nM. SPSB2-iNOS inhibitory cyclic peptide-2 TFA is reduction-resistant and oxidatively stable[1].

Product Specifications

UNSPSC

12352209

Target

NO Synthase

Type

Peptides

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/spsb2-inos-inhibitory-cyclic-peptide-2-tfa.html

Solubility

10 mM in DMSO

Smiles

O=C(N[C@H](C(N[C@@](C(N[C@H](C(N[C@H](C(N[C@H](C(NCCC(N1)=O)=O)CC(N)=O)=O)CC(N)=O)=O)CC(N)=O)=O)([H])[C@@H](C)CC)=O)CC(O)=O)[C@@H]1CC2=CNC3=CC=CC=C23.O=C(C(F)(F)F)O.[x]

Molecular Formula

C36H49N11O12.xC2HF3O2

Molecular Weight

827.84 (free acid)

References & Citations

[1]Yap BK, et al., Redox-stable cyclic peptide inhibitors of the SPSB2-iNOS interaction. FEBS Lett. 2016 Mar;590 (6) :696-704.

Shipping Conditions

Room temperature

Scientific Category

Peptides

Clinical Information

No Development Reported

Frequently Asked Questions

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