Linaclotide
Linaclotide is a potent and selective guanylate cyclase C agonist; developed for the treatment of constipation-predominant irritable bowel syndrome (IBS-C) and chronic constipation.
Product Specifications
CAS Number
851199-59-2
UNSPSC
12352209
Hazard Statement
H302
Target
Guanylate Cyclase
Type
Reference compound
Related Pathways
GPCR/G Protein
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Linaclotide.html
Purity
99.77
Solubility
DMSO : 50 mg/mL (ultrasonic) |H2O : 16.67 mg/mL (ultrasonic; adjust pH to 2 with HCl)
Smiles
O=C([C@@H](NC([C@@](CSSC[C@@H]1N)([H])NC([C@@](CSSC[C@H](N2)C(N[C@H](C(O)=O)CC3=CC=C(O)C=C3)=O)([H])NC([C@@H](NC([C@@H](N4)CCC(O)=O)=O)CC5=CC=C(O)C=C5)=O)=O)=O)CC(N)=O)N6[C@@](C(N[C@H](C(N[C@](CSSC[C@](C4=O)([H])NC1=O)([H])C(NC(C(NCC2=O)=O)[C@H](O)C)=O)=O)C)=O)([H])CCC6
Molecular Formula
C59H79N15O21S6
Molecular Weight
1526.74
Precautions
H302
References & Citations
[1]Bryant AP, et al. Linaclotide is a potent and selective guanylate cyclase C agonist that elicits pharmacological effects locally in the gastrointestinal tract. Life Sci. 2010 May 8;86 (19-20) :760-5.|[2]Love BL, et al. Linaclotide: a novel agent for chronic constipation and irritable bowel syndrome. Am J Health Syst Pharm. 2014 Jul 1;71 (13) :1081-91.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
PKSM040569 100 µg
Recombinant Mouse Syndecan-1/SDC1 Protein (His Tag)
Sign In for Pricing
View Details 
BNC042750-500 1x 500 µL
S100A4 (Marker of Tumor Metastasis) (S100A4/2750R), CF405S conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC402545-500 1x 500 µL
CD73 (Immuno-Oncology Target) (NT5E/2545), CF640R conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
MTW21F4-NA/W 10x 96 Well Plates
Neutravidin Coated - 96 well plates - 8 Well Strips on 12 x 8 frame - White PS
Sign In for Pricing
View Details 