MMV008138

MMV008138 is a species-selective IspD (enzyme 2-C-methyl-d-erythritol 4-phosphate cytidylyltransferase) -targeting antimalarial agent, with an IC50 of 44 nM for PfIspD (P. falciparum IspD) . MMV008138 inhibits the growth of P. falciparum Dd2 strain with an IC50 of 250 nM[1][2].

Product Specifications

CAS Number

[1679333-73-3]

UNSPSC

12352005

Target

Parasite

Type

Reference compound

Related Pathways

Anti-infection

Applications

Neuroscience-Neuromodulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/mmv008138.html

Concentration

10mM

Purity

98.49

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C([C@@H]1CC2=C([C@@H](C3=CC=C(Cl)C=C3Cl)N1)NC4=C2C=CC=C4)O

Molecular Formula

C18H14Cl2N2O2

Molecular Weight

361.22

References & Citations

[1]Ghavami M, et al. Biological Studies and Target Engagement of the 2- C-Methyl-d-Erythritol 4-Phosphate Cytidylyltransferase (IspD) -Targeting Antimalarial Agent (1 R,3 S) -MMV008138 and Analogs. ACS Infect Dis. 2018 Apr 13;4 (4) :549-559.|[2]Yao ZK, et al. Determination of the active stereoisomer of the MEP pathway-targeting antimalarial agent MMV008138, and initial structure-activity studies. Bioorg Med Chem Lett. 2015 Apr 1;25 (7) :1515-9.