Human 5-HT2AR Protein (S162K, M164W, S372N), Flag, His Tag (Detergent)

This gene encodes one of the receptors for serotonin, a neurotransmitter with many roles. Mutations in this gene are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated with response to the antidepressant citalopram in patients with major depressive disorder (MDD) . MDD patients who also have a mutation in intron 2 of this gene show a significantly reduced response to citalopram as this antidepressant downregulates expression of this gene. Multiple transcript variants encoding different isoforms have been found for this gene.

Product Specifications

Background

Specifications

This protein carries a flag tag at the N-terminus and a polyhistidine tag at the C-terminus. The protein has a calculated MW of 55.3 kDa.

Accession Number

P28223-1 (S162K, M164W, S372N)

Expression Region

Asp 2 - Ala 265 & Gln 313 - Lys 403

Host

Insect Cells

Target

5-HT2AR

Conjugation

Unconjugated

Tag

N-Flag & C-10xHis

Source

Human

Stability

The product MUST be stored at -70°C or lower upon receipt; -70°C for 3 months under sterile conditions.

Endotoxin

1.0 EU per μg

Purity

90%

Bioactivity

Immobilized Human 5-HT2AR Protein (S162K, M164W, S372N), Flag,His Tag (Cat. No. 5HR-H55D3) at 5 μg/mL (100 μL/well) can bind Anti-5-HT2AR Antibody with a linear range of 0.02-0.625 μg/mL (QC tested).