Hygromycin B
Hygromycin B is an aminoglycoside antibiotic active against prokaryotic and eukaryotic cells.
Product Specifications
CAS Number
31282-04-9
Product Name Alternative
Hygrovetine
UNSPSC
12352005
Hazard Statement
H300+H310+H330
Target
Antibiotic; Bacterial; Fungal; Parasite
Type
Natural Products
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/Hygromycin-B.html
Purity
99.93
Solubility
DMSO : 66.67 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 125 mg/mL (ultrasonic)
Smiles
O[C@H]([C@H]1O)C2(O[C@@]([C@@H](N)CO)([H])[C@@H]1O)O[C@@]([C@@H](O[C@@H]3CO)O[C@@]([C@H]([C@H](N)C4)O)([H])[C@@H]([C@H]4NC)O)([H])[C@@]([C@H]3O)([H])O2
Molecular Formula
C20H37N3O13
Molecular Weight
527.52
Precautions
H300+H310+H330
References & Citations
[1]Pardo JM, et al. Biochemical basis of resistance to hygromycin B in Streptomyces hygroscopicus--the producing organism. J Gen Microbiol. 1985 Jun;131 (6) :1289-98.|[2]González A, et al. Studies on the mode of action of hygromycin B, an inhibitor of translocation in eukaryotes. Biochim Biophys Acta. 1978 Dec 21;521 (2) :459-69.|[3]Pfister P, et al. Role of 16S rRNA Helix 44 in Ribosomal Resistance to Hygromycin B. Antimicrob Agents Chemother. 2003 May;47 (5) :1496-502.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Aminoglycoside
Available Sizes
Frequently Asked Questions
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