Hygromycin B

Hygromycin B is an aminoglycoside antibiotic active against prokaryotic and eukaryotic cells.

Product Specifications

CAS Number

[31282-04-9]

Product Name Alternative

Hygrovetine

UNSPSC

12352005

Hazard Statement

H300+H310+H330

Target

Antibiotic; Bacterial; Fungal; Parasite

Type

Natural Products

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/Hygromycin-B.html

Purity

99.93

Solubility

DMSO : 66.67 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 125 mg/mL (ultrasonic)

Smiles

O[C@H]([C@H]1O)C2(O[C@@]([C@@H](N)CO)([H])[C@@H]1O)O[C@@]([C@@H](O[C@@H]3CO)O[C@@]([C@H]([C@H](N)C4)O)([H])[C@@H]([C@H]4NC)O)([H])[C@@]([C@H]3O)([H])O2

Molecular Formula

C20H37N3O13

Molecular Weight

527.52

Precautions

H300+H310+H330

References & Citations

[1]Pardo JM, et al. Biochemical basis of resistance to hygromycin B in Streptomyces hygroscopicus--the producing organism. J Gen Microbiol. 1985 Jun;131 (6) :1289-98.|[2]González A, et al. Studies on the mode of action of hygromycin B, an inhibitor of translocation in eukaryotes. Biochim Biophys Acta. 1978 Dec 21;521 (2) :459-69.|[3]Pfister P, et al. Role of 16S rRNA Helix 44 in Ribosomal Resistance to Hygromycin B. Antimicrob Agents Chemother. 2003 May;47 (5) :1496-502.