Anti-Hu CD307a PE
CD307a is a type I transmembrane glycoprotein of the Fc receptor family. It contains two ITAM motifs in its cytoplasmic domain. CD307a is expressed mainly on the surface of mature B-cells, and is down-regulated in germinal center B-cells. Expression of CD307a is higher in patients with autoimmune diseases, compared with healthy controls.
Product Specifications
Certification
RUO
Reactivity
Human
Immunogen
DNA-immunization followed by a boost with the CD307a transfected cells
Target Antigen
CD307a
Clone
E3
Applications
FC (QC tested)
Format
PE
Buffer
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
References & Citations
*Li H, Borrego F, Nagata S, Tolnay M: Fc receptor-like 5 expression distinguishes two distinct subsets of human circulating tissue-like memory B cells. J Immunol. 2016 May 15;196 (10) :4064-74., URL: https://pubmed.ncbi.nlm.nih.gov/27076679/, *Du X, Nagata S, Ise T, Stetler-Stevenson M, Pastan I: FCRL1 on chronic lymphocytic leukemia, hairy cell leukemia, and B-cell non-Hodgkin lymphoma as a target of immunotoxins. Blood. 2008 Jan 1;111 (1) :338-43, URL: https://pubmed.ncbi.nlm.nih.gov/17895404/, *Nagata S, Ise T, Pastan I: Fc receptor-like 3 protein expressed on IL-2 nonresponsive subset of human regulatory T cells. J Immunol. 2009 Jun 15;182 (12) :7518-26, URL: https://www.ncbi.nlm.nih.gov/pubmed/19494275
Storage Conditions
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Specificity
The mouse monoclonal antibody E3 recognizes an extracellular epitope of CD307a, a transmembrane glycoprotein expressed predominantly on the surface of mature B cells.
Applications Notes
6
Isotype
Mouse IgG1 kappa
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