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Anti-Hu CD307a PE

CD307a is a type I transmembrane glycoprotein of the Fc receptor family. It contains two ITAM motifs in its cytoplasmic domain. CD307a is expressed mainly on the surface of mature B-cells, and is down-regulated in germinal center B-cells. Expression of CD307a is higher in patients with autoimmune diseases, compared with healthy controls.

Product Specifications

Certification

RUO

Reactivity

Human

Immunogen

DNA-immunization followed by a boost with the CD307a transfected cells

Target Antigen

CD307a

Clone

E3

Applications

FC (QC tested)

Format

PE

Buffer

Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

References & Citations

*Li H, Borrego F, Nagata S, Tolnay M: Fc receptor-like 5 expression distinguishes two distinct subsets of human circulating tissue-like memory B cells. J Immunol. 2016 May 15;196 (10) :4064-74., URL: https://pubmed.ncbi.nlm.nih.gov/27076679/, *Du X, Nagata S, Ise T, Stetler-Stevenson M, Pastan I: FCRL1 on chronic lymphocytic leukemia, hairy cell leukemia, and B-cell non-Hodgkin lymphoma as a target of immunotoxins. Blood. 2008 Jan 1;111 (1) :338-43, URL: https://pubmed.ncbi.nlm.nih.gov/17895404/, *Nagata S, Ise T, Pastan I: Fc receptor-like 3 protein expressed on IL-2 nonresponsive subset of human regulatory T cells. J Immunol. 2009 Jun 15;182 (12) :7518-26, URL: https://www.ncbi.nlm.nih.gov/pubmed/19494275

Storage Conditions

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Specificity

The mouse monoclonal antibody E3 recognizes an extracellular epitope of CD307a, a transmembrane glycoprotein expressed predominantly on the surface of mature B cells.

Applications Notes

6

Isotype

Mouse IgG1 kappa

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