HIOC

HIOC is a potent and selective activator of TrkB (tropomyosin related kinase B) receptor. HIOC can pass the blood-brain and blood-retinal barriers.HIOC activates TrkB/ERK pathway and decreases neuronal cell apoptosis. HIOC attenuates early brain injury after SAH (subarachnoid hemorrhage) . HIOC shows protective activity in an animal model for light-induced retinal degeneration[1][2][3].

Product Specifications

CAS Number

[314054-36-9]

UNSPSC

12352005

Target

Apoptosis; ERK; Trk Receptor

Type

Reference compound

Related Pathways

Apoptosis; MAPK/ERK Pathway; Neuronal Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/hioc.html

Purity

99.94

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1C(NCCC1)=O)NCCC2=CNC3=C2C=C(O)C=C3

Molecular Formula

C16H19N3O3

Molecular Weight

301.34

References & Citations

[1]Tang J, et al. Neuroprotective role of an N-acetyl serotonin derivative via activation of tropomyosin-related kinase receptor B after subarachnoid hemorrhage in a rat model. Neurobiol Dis. 2015 Jun;78:126-33. |[2]Noah A.Setterholm, et al.Gram-scale, chemoselective synthesis of N-[2- (5-hydroxy-1H-indol-3-yl) ethyl]-2-oxopiperidine-3-carboxamide (HIOC) . Tetrahedron Letters. 3 June 2015;56 (23) :3413-3415.|[3]Ying Li, et al. Effect of systemic treatment with N-[2- (5-hydroxy-1H-indol-3-yl) ethyl]-2-oxopiperidine-3- carboxamide (HIOC) or tauroursodeoxycholic Acid (TUDCA) on retinal ganglion cell death following optic nerve crush. bioRxiv. 2019 August 14.