HIOC
HIOC is a potent and selective activator of TrkB (tropomyosin related kinase B) receptor. HIOC can pass the blood-brain and blood-retinal barriers.HIOC activates TrkB/ERK pathway and decreases neuronal cell apoptosis. HIOC attenuates early brain injury after SAH (subarachnoid hemorrhage) . HIOC shows protective activity in an animal model for light-induced retinal degeneration[1][2][3].
Product Specifications
CAS Number
314054-36-9
UNSPSC
12352005
Target
Apoptosis; ERK; Trk Receptor
Type
Reference compound
Related Pathways
Apoptosis; MAPK/ERK Pathway; Neuronal Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/hioc.html
Purity
99.94
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1C(NCCC1)=O)NCCC2=CNC3=C2C=C(O)C=C3
Molecular Formula
C16H19N3O3
Molecular Weight
301.34
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ERK; TrkB
Available Sizes
Frequently Asked Questions
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