Soyasaponin Bb

Soyasaponin Bb is an orally active, covalent inducer of heme oxygenase HO-1 and an inhibitor of aldose reductase AKR1B1. Soyasaponin Bb can regulate oxidative stress pathways, enhance antioxidant capacity, reduce reactive oxygen species (ROS) generation, and inhibit lipid peroxidation and hepatocyte apoptosis. Soyasaponin Bb improves alcohol-induced hepatocyte membrane damage and liver function abnormalities, and improves Scopolamine (HY-N0296) -induced memory impairment. Soyasaponin Bb has antioxidant, hepatoprotective, and neuroprotective activities[1][2][3][4].

Product Specifications

CAS Number

[51330-27-9]

UNSPSC

12352005

Target

Aldose Reductase; Apoptosis; Heme Oxygenase (HO) ; Reactive Oxygen Species (ROS)

Type

Natural Products

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/soyasaponin-bb.html

Purity

99.88

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O[C@H]([C@H]1O[C@@]2([H])[C@H](O[C@]3([H])O[C@@H](C)[C@H](O)[C@@H](O)[C@H]3O)[C@@H](O)[C@@H](O)[C@@H](CO)O2)[C@H](O)[C@@H](C(O)=O)O[C@@]1([H])O[C@@H]4[C@@](CO)(C)[C@]5([H])CC[C@@]6(C)[C@]7(C)CC[C@@]8(C)[C@H](O)CC(C)(C)C[C@@]8([H])C7=CC[C@]6([H])[C@@]5(C)CC4

Molecular Formula

C48H78O18

Molecular Weight

943.12

References & Citations

[1]Lijie Z, et al. Soyasaponin Bb Protects Rat Hepatocytes from Alcohol-Induced Oxidative Stress by Inducing Heme Oxygenase-1. Pharmacogn Mag. 2016 Oct-Dec;12 (48) :302-306|[2]Xiao L, et al. Soyasaponin Bb has poor absorption and bioavailability in Sprague–Dawley rats and Caco-2 intestinal epithelial cell model[J]. Food, Nutrition and Health, 2025, 2 (1) : 1-13.|[3]Hong SW, et al. Soyasaponins Ab and Bb prevent scopolamine-induced memory impairment in mice without the inhibition of acetylcholinesterase. J Agric Food Chem. 2014 Mar 5;62 (9) :2062-8.|[4]Balestri F, et al. Soyasaponins from Zolfino bean as aldose reductase differential inhibitors. J Enzyme Inhib Med Chem. 2019 Dec;34 (1) :350-360.