Caspase-9 Monoclonal Antibody

Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates effector caspases caspase-3 (CASP3) or caspase-7 (CASP7) . Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly (ADP-ribose) polymerase (PARP) .

Apoptosis related cysteine peptidase; Apoptotic protease-activating factor 3; Caspase 9 apoptosis related cysteine peptidase; Caspase 9 Dominant Negative; Caspase 9c; Caspase-9 subunit p10; ICE LAP6; ICE like apoptotic protease 6; ICE-like apoptotic protease 6; protein phosphatase 1; regulatory subunit 56; RNCASP9; MCH; Apoptotic protease Mch; PPP1R; ICE-LAP; CASP9; APAF-3; APAF3; ICE-LAP6; MCH6; PPP1R56; caspase-9; Caspase 9; CASP-9; Apoptotic protease Mch-6; Apoptotic protease-activating factor 3 (APAF-3) ; ICE-like apoptotic protease 6 (ICE-LAP6)