Latrepirdine

Latrepirdine is a neuroactive compound with antagonist activity at histaminergic, α-adrenergic, and serotonergic receptors. Latrepirdine stimulates amyloid precursor protein (APP) catabolism and amyloid-β (Aβ) secretion.

Product Specifications

CAS Number

[3613-73-8]

Product Name Alternative

Dimebolin; Dimebone

UNSPSC

12352005

Hazard Statement

H302-H315-H320-H335

Target

5-HT Receptor; Adrenergic Receptor; Amyloid-β; Autophagy; Histamine Receptor

Type

Reference compound

Related Pathways

Autophagy; GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/Latrepirdine.html

Purity

99.19

Solubility

DMSO : 50 mg/mL (ultrasonic; warming)

Smiles

CC1=CC=C(CCN2C3=C(CN(C)CC3)C4=C2C=CC(C)=C4)C=N1

Molecular Formula

C21H25N3

Molecular Weight

319.44

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]Steele JW, et al. Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model. Mol Psychiatry. 2013 Aug;18 (8) :889-97.