KDM5-IN-1
KDM5-IN-1 is a potent, selective and orally bioavailable KDM5 inhibitor with an IC50 of 15.1 nM.
Product Specifications
CAS Number
[1628210-26-3]
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
Histone Demethylase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/KDM5-in-1.html
Purity
99.52
Solubility
DMSO : ≥ 30 mg/mL
Smiles
N#CC1=C2NC(C3=CN(C(C)(C)C)N=C3)=C(C(C)C)C(N2N=C1)=O
Molecular Formula
C17H20N6O
Molecular Weight
324.38
Precautions
H315, H319, H320
References & Citations
[1]Liang J, et al. Lead optimization of a pyrazolo[1,5-a]pyrimidin-7 (4H) -one scaffold to identify potent, selective and orally bioavailable KDM5 inhibitors suitable for in vivo biological studies. Bioorg Med Chem Lett. 2016 Aug 15;26 (16) :4036-41.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
KDM5
Available Sizes
Curated Selection
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