UPF-1035

UPF-1035 is a selective PARP-2 inhibitor with an IC50 value of 0.15 μM. UPF-1035 increases CA1 pyramidal cell loss in hippocampal and has neuroprotective activity[1].

Product Specifications

CAS Number

[370872-09-6]

UNSPSC

12352005

Target

PARP

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/upf-1035.html

Smiles

O=C1C2=CC=CC(OC(C3=CC=CC=C3)=O)=C2C=CN1

Molecular Formula

C16H11NO3

Molecular Weight

265.26

References & Citations

[1]F Moroni , et al. Selective PARP-2 inhibitors increase apoptosis in hippocampal slices but protect cortical cells in models of post-ischaemic brain damage. Br J Pharmacol. 2009 Jul;157 (5) :854-62.