Vitamin K1-13C6

Vitamin K1-13C6 is the 13C-labeled Vitamin K1. Vitamin K1 a naturally occurring vitamin required for blood coagulation and bone and vascular metabolism.

Product Specifications

Product Name Alternative

Phylloquinone-13C6; Phytomenadione-13C6

UNSPSC

12352005

Target

Endogenous Metabolite; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Metabolic Enzyme/Protease; Others

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/vitamin-k1-13c6.html

Concentration

109.5 μM * 1 mL in Ethanol

Purity

99.12

Solubility

10 mM in DMSO|DMF : ≥ 25mg/mL|DMSO : ≥ 25mg/mL|Ethanol : ≥ 25mg/mL

Smiles

O=C1C(C)=C(C/C=C(C)/CCC[C@H](C)CCC[C@H](C)CCCC(C)C)C([13C]2=[13C]1[13C]=[13C][13C]=[13C]2)=O

Molecular Formula

C25 13C6H46O2

Molecular Weight

456.62

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Basset GJ, et al. Phylloquinone (Vitamin K1) : Occurrence, Biosynthesis and Functions. Mini Rev Med Chem. 2016 Jun 22.|[3]Orlando A, et al. Vitamin K1 exerts antiproliferative effects and induces apoptosis in three differently graded human colon cancer cell lines. Biomed Res Int. 2015;2015:296721.|[4]Ibarrola-Jurado N, et al. Dietary phylloquinone intake and risk of type 2 diabetes in elderly subjects at high risk of cardiovascular disease. Am J Clin Nutr. 2012 Nov;96 (5) :1113-8.|[5]Kim M, et al. Vitamin K1 (phylloquinone) and K2 (menaquinone-4) supplementation improves bone formation in a high-fat diet-induced obese mice. J Clin Biochem Nutr. 2013 Sep;53 (2) :108-13.|[6]Hemmati AA, et al. Topical vitamin K1 promotes repair of full thickness wound in rat. Indian J Pharmacol. 2014 Jul-Aug;46 (4) :409-12.