Mivacurium (dichloride)

Mivacurium dichloride is a benzylisoquinoline derivative and is a short-acting non-depolarizing neuromuscular blocking agent and skeletal muscle relaxant. Mivacurium dichloride couples with the nAChR to reduce or inhibit the depolarizing effect of acetylcholine on the terminal disc of the muscle cell[1][2][3].

Product Specifications

CAS Number

[106861-44-3]

UNSPSC

12352005

Hazard Statement

H301

Target

NAChR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/mivacurium-dichloride.html

Purity

99.35

Solubility

DMSO : 250 mg/mL (ultrasonic) |H2O : ≥ 100 mg/mL

Smiles

O=C(OCCC[N+]1(C)[C@H](CC2=CC(OC)=C(OC)C(OC)=C2)C3=C(C=C(OC)C(OC)=C3)CC1)CC/C=C/CCC(OCCC[N+]4(C)[C@H](CC5=CC(OC)=C(OC)C(OC)=C5)C6=C(C=C(OC)C(OC)=C6)CC4)=O.[Cl-].[Cl-]

Molecular Formula

C58H80Cl2N2O14

Molecular Weight

1100.17

Precautions

P264-P270-P330-P405-P501

References & Citations

[1]Delu Che, et al. Mivacurium Induce Mast Cell Activation and Pseudo-Allergic Reactions via MAS-related G Protein Coupled receptor-X2. Cell Immunol. 2018 Oct;332:121-128.|[2]J E Caldwell. New Skeletal Muscle Relaxants. Int Anesthesiol Clin. Winter 1995;33 (1) :39-60.|[3]Matthias Paul, et al. The Potency of New Muscle Relaxants on Recombinant Muscle-Type Acetylcholine Receptors. Anesth Analg. 2002 Mar;94 (3) :597-603; table of contents.