Boc-Asp (OMe) -fluoromethyl ketone

Boc-Asp (OME) -Fluoromethyl Ketone is a broad range caspase inhibitor that inhibits Fas-mediated phagocytosis and oxidative rupture inhibition, but does not affect the chemotactic activity of IL-8[1][2].

Product Specifications

CAS Number

[187389-53-3]

Product Name Alternative

Boc-Asp (OMe) -FMK

UNSPSC

12352211

Hazard Statement

H319

Target

Caspase

Type

Reference compound

Related Pathways

Apoptosis

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/boc-asp-ome-fluoromethyl-ketone.html

Purity

98.0

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C(OC)C[C@H](NC(OC(C)(C)C)=O)C(CF)=O

Molecular Formula

C11H18FNO5

Molecular Weight

263.26

Precautions

H319

References & Citations

[1]Paunel-Görgülü A, et al. Stimulation of Fas signaling down-regulates activity of neutrophils from major trauma patients with SIRS. Immunobiology. 2011;216 (3) :334-342.|[2]Koike A, et al. Pan-caspase inhibitors induce necroptosis via ROS-mediated activation of mixed lineage kinase domain-like protein and p38 in classically activated macrophages. Exp Cell Res. 2019;380 (2) :171-179.