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Adenosine 3′-monophosphate

Adenosine 3’-monophosphate (3’-AMP) is a nucleotide. Adenosine 3’-monophosphate is a cyclic AMP production agonist. Adenosine 3’-monophosphate increases cyclic AMP levels concentration-dependently in NG108-15 cells. Adenosine 3’-monophosphate can be used in the determination of acid phosphatase activity of human serum, which is estabilished as a laboratory procedure in the diagnosis of prostate cancer, metastatic mammary cancer and Gaucher’s disease. Adenosine 3’-monophosphate inhibits human aortic and coronary vascular smooth muscle cell proliferation via A2B receptors[1][2][3].

Product Specifications

CAS Number

84-21-9

Product Name Alternative

3′-AMP

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Cyclic GMP-AMP Synthase; Nucleoside Antimetabolite/Analog

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/adenosine-3-monophosphate.html

Purity

99

Solubility

H2O : 0.5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

NC1=C2C(N([C@@H]3O[C@H](CO)[C@@H](OP(O)(O)=O)[C@H]3O)C=N2)=NC=N1

Molecular Formula

C10H14N5O7P

Molecular Weight

347.22

Precautions

H302, H315, H319, H335

References & Citations

[1]S Ohkubo, et al. Effects of AMP derivatives on cyclic AMP levels in NG108-15 cells. Br J Pharmacol. 2000 Mar;129 (6) :1244-50. |[2]Ellis, G., et al., (1971) . Colorimetric determination of serum acid phosphatase activity using adenosine 3'-monophosphate as substrate. Journal of clinical pathology, 24 (6), 493–500. |[3]Jackson, E. K., et al., (2011) . 2',3'-cAMP, 3'-AMP, and 2'-AMP inhibit human aortic and coronary vascular smooth muscle cell proliferation via A2B receptors. American journal of physiology. Heart and circulatory physiology, 301 (2), H391–H401.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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