Adenosine 3′-monophosphate

Adenosine 3’-monophosphate (3’-AMP) is a nucleotide. Adenosine 3’-monophosphate is a cyclic AMP production agonist. Adenosine 3’-monophosphate increases cyclic AMP levels concentration-dependently in NG108-15 cells. Adenosine 3’-monophosphate can be used in the determination of acid phosphatase activity of human serum, which is estabilished as a laboratory procedure in the diagnosis of prostate cancer, metastatic mammary cancer and Gaucher’s disease. Adenosine 3’-monophosphate inhibits human aortic and coronary vascular smooth muscle cell proliferation via A2B receptors[1][2][3].

Product Specifications

CAS Number

[84-21-9]

Product Name Alternative

3′-AMP

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Cyclic GMP-AMP Synthase; Nucleoside Antimetabolite/Analog

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/adenosine-3-monophosphate.html

Purity

Solubility

H2O : 0.5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

NC1=C2C(N([C@@H]3O[C@H](CO)[C@@H](OP(O)(O)=O)[C@H]3O)C=N2)=NC=N1

Molecular Formula

C10H14N5O7P

Molecular Weight

347.22

Precautions

H302, H315, H319, H335

References & Citations

[1]S Ohkubo, et al. Effects of AMP derivatives on cyclic AMP levels in NG108-15 cells. Br J Pharmacol. 2000 Mar;129 (6) :1244-50. |[2]Ellis, G., et al., (1971) . Colorimetric determination of serum acid phosphatase activity using adenosine 3'-monophosphate as substrate. Journal of clinical pathology, 24 (6), 493–500. |[3]Jackson, E. K., et al., (2011) . 2',3'-cAMP, 3'-AMP, and 2'-AMP inhibit human aortic and coronary vascular smooth muscle cell proliferation via A2B receptors. American journal of physiology. Heart and circulatory physiology, 301 (2), H391–H401.