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Frunexian

Frunexian (EP-7041) is a selective and potent inhibitor of coagulation factor XI/activated factor XI, targeting to factor XIa. Frunexian exhibits antithrombotic activity, with no bleeding liability in rat mesenteric arterial puncture model. Frunexian can be used in extracorporeal membrane oxygenation (ECMO) research[1].

Product Specifications

CAS Number

1803270-60-1

Product Name Alternative

EP-7041

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Factor XI

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/frunexian.html

Purity

97.16

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC([C@@H](N(C1=O)C(N[C@@H](C2CCCCC2)C)=O)[C@H]1CC3=CC=NC(N)=C3)=O

Molecular Formula

C19H26N4O4

Molecular Weight

374.43

Precautions

H302, H315, H319, H335

References & Citations

[1]Pollack CV Jr, et al. EP-7041, a Factor XIa Inhibitor as a Potential Antithrombotic Strategy in Extracorporeal Membrane Oxygenation: A Brief Report. Crit Care Explor. 2020 Sep 15;2 (9) :e0196.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 2

Available Sizes

Frequently Asked Questions

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