MSA-2

MSA-2, a potent and orally available non-nucleotide STING agonist, is bound to STING as a noncovalent dimer with nanomolar affinity. MSA-2 shows EC50s of 8.3 and 24 μM for human STING isoforms WT and HAQ, respectively. MSA-2 stimulates interferon-β secretion in tumors, induces tumor regression with durable antitumor immunity, and synergizes with anti-PD-1 in syngeneic mouse tumor models[1][2].

Product Specifications

CAS Number

[129425-81-6]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

STING

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/msa-2.html

Purity

99.81

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(C1=CC(C(S1)=C2)=CC(OC)=C2OC)CCC(O)=O

Molecular Formula

C14H14O5S

Molecular Weight

294.32

Precautions

H302, H315, H319, H335

References & Citations

[1]Pan BS, et al. An orally available non-nucleotide STING agonist with antitumor activity. Science. 2020;369 (6506) :eaba6098.|[2]Liu J, et al. Identification of MSA-2: An oral antitumor non-nucleotide STING agonist. Signal Transduct Target Ther. 2021;6 (1) :18. Published 2021 Jan 12.