TLX agonist 2
TLX agonist 2 (compound 31) is a TLX agonist (EC50=0.1 μM; Kd=0.16 μM) . TLX agonist 2 promotes TLX transcriptional activity and enhances the expression of TLX target genes by binding to TLX. TLX agonist 2 can be used in the study of neurodegenerative diseases[1].
Product Specifications
UNSPSC
12352005
Target
Orphan Nuclear Receptor; Orphan Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/tlx-agonist-2.html
Smiles
O=C(NC1=CC(C(F)(F)F)=CC(NC(C2=NN(C(C)=C2)C)=O)=C1)C3=CC=NC4=C3C=CC=C4
Molecular Formula
C23H18F3N5O2
Molecular Weight
453.42
References & Citations
[1]Hank, et al. "Development of tailless homologue receptor (TLX) agonist chemical tools." Journal of Medicinal Chemistry (2024) .
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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