ATX-1905
ATX-1905 is a positron emission tomography (PET) tracer that demonstrates good autotaxin (ATX) binding specificity and achieves semiquantification of lung ATX expression levels, which are elevated in fibrotic lungs. ATX-1905 exhibits elevated uptake in Bleomycin (HY-108345) -induced pulmonary fibrosis (BPF) lungs. ATX-1905 is promising for research of idiopathic pulmonary fibrosis (IPF) [1].
Product Specifications
CAS Number
[3035983-65-1]
UNSPSC
12352005
Target
Phosphodiesterase (PDE)
Type
Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Others
Smiles
[2H]C(Cl)(C([2H])(N1CCN(CC1)C(CN2CCN(CC2)C3=CN4C(C=C3)=NC(CC)=C4N(C5=NC(C6=CC=C(C=C6)F)=C(S5)C#N)C)=O)[2H])[2H]
Molecular Formula
C32H33D4ClFN9OS
Molecular Weight
654.24
References & Citations
[1]Deng X, et al. Imaging Pulmonary Fibrosis and Treatment Efficacy In Vivo with Autotaxin-Specific PET Ligand [18F]ATX-1905. Mol Pharm. 2024 Aug 26.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
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