Insulin-like Growth factor-2 (Human)

<strong>Insulin-like Growth factor-2 (Human)</strong>_x000D_ <strong>Catalog number:</strong> B2010279_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Volume/Weight:</strong> 10 ug_x000D_ <strong>pH:</strong> 7.4 upon reconstitution_x000D_ <strong>Supplied as:</strong> Lyophilized Powder_x000D_ <strong>Appearance:</strong> Powder_x000D_ <strong>Applications:</strong> highly pure Insulin-like Growth factor-2 (Human) expressed in E. coli . This protein acts as a mitogenic cytokine that binds to IGF type 1 receptor and is involved in modulating the growth in many tissues._x000D_ <strong>Storage:</strong> -20C_x000D_ <strong>Keywords:</strong> rHuIGF-2; Somatamedin A; IGF-II_x000D_ <strong>Grade:</strong> Biotechnology grade. All components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Holly JMP, Biernacka K, Perks CM. The Neglected Insulin: IGF-II, a Metabolic_x000D_ Regulator with Implications for Diabetes, Obesity, and Cancer. Cells. 2019 Oct_x000D_ 6;8(10):1207._x000D_ _x000D_ 2: Bach LA. Current ideas on the biology of IGFBP-6: More than an IGF-II_x000D_ inhibitor? Growth Horm IGF Res. 2016 Oct-Dec;30-31:81-86._x000D_ _x000D_ 3: Steinmetz AB, Stern SA, Kohtz AS, Descalzi G, Alberini CM. Insulin-Like_x000D_ Growth Factor II Targets the mTOR Pathway to Reverse Autism-Like Phenotypes in_x000D_ Mice. J Neurosci. 2018 Jan 24;38(4):1015-1029._x000D_ _x000D_ 4: Cottam Jones JM, Harris PW, Scanlon DB, Forbes BE, Brimble MA, Abell AD._x000D_ Fluorescent IGF-II analogues for FRET-based investigations into the binding of_x000D_ IGF-II to the IGF-1R. Org Biomol Chem. 2016 Mar 7;14(9):2698-705._x000D_ _x000D_ 5: Lauterio TJ. The effects of IGF-I and IGF-II on cell growth and_x000D_ differentiation in the central nervous system. Adv Exp Med Biol. 1992;321:31-6._x000D_ _x000D_ 6: Kiess W, Yang Y, Kessler U, Hoeflich A. Insulin-like growth factor II (IGF-_x000D_ II) and the IGF-II/mannose-6-phosphate receptor: the myth continues. Horm Res._x000D_ 1994;41 Suppl 2:66-73._x000D_ _x000D_ 7: Brown J, Jones EY, Forbes BE. Keeping IGF-II under control: lessons from the_x000D_ IGF-II-IGF2R crystal structure. Trends Biochem Sci. 2009 Dec;34(12):612-9._x000D_ _x000D_ 8: Charnock JC, Dilworth MR, Aplin JD, Sibley CP, Westwood M, Crocker IP. The_x000D_ impact of a human IGF-II analog ([Leu27]IGF-II) on fetal growth in a mouse model_x000D_ of fetal growth restriction. Am J Physiol Endocrinol Metab. 2016 Jan_x000D_ 1;310(1):E24-31._x000D_ _x000D_ 9: Giudice LC, Lamson G, Rosenfeld RG, Irwin JC. Insulin-like growth factor-II_x000D_ (IGF-II) and IGF binding proteins in human endometrium. Ann N Y Acad Sci._x000D_ 1991;626:295-307._x000D_ _x000D_ 10: Bradley JP, Han VK, Roth DA, Levine JP, McCarthy JG, Longaker MT. Increased_x000D_ IGF-I and IGF-II mRNA and IGF-I peptide in fusing rat cranial sutures suggest_x000D_ evidence for a paracrine role of insulin-like growth factors in suture fusion._x000D_ Plast Reconstr Surg. 1999 Jul;104(1):129-38._x000D_ _x000D_ 11: O'Dell SD, Day IN. Insulin-like growth factor II (IGF-II). Int J Biochem_x000D_ Cell Biol. 1998 Jul;30(7):767-71._x000D_ _x000D_ 12: Weber MM, Melmed S, Rosenbloom J, Yamasaki H, Prager D. Rat somatotroph_x000D_ insulin-like growth factor-II (IGF-II) signaling: role of the IGF-I receptor._x000D_ Endocrinology. 1992 Nov;131(5):2147-53._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/19251056/">13: Brown J, Jones EY, Forbes BE. Interactions of IGF-II with the IGF2R/cation-_x000D_ independent mannose-6-phosphate receptor mechanism and biological outcomes._x000D_ Vitam Horm. 2009;80:699-719. </a>_x000D_ _x000D_ <strong>Products Related to Insulin-like Growth factor-2 (Human) </strong> <a href="https://moleculardepot.com/product-category/Proteins/">: Proteins</a>