TNF-α-IN-6
TNF-α-IN-6 (compound 12) is an orally effective allosteric inhibitor of TNFα (KD = 6.8 nM) . TNF-α-IN-6 has anti-inflammatory effects[1].
Product Specifications
CAS Number
[2699704-20-4]
UNSPSC
12352005
Target
TNF Receptor
Type
Reference compound
Related Pathways
Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/tnf-α-in-6.html
Concentration
10mM
Purity
99.58
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
N#CC1=NC=CC=C1CN(C2=NC(C3=CN=C(N4C[C@]5([H])N(C(NC5)=O)CC4)N=C3)=CC=C26)C(C)(C)C6=O
Molecular Formula
C26H25N9O2
Molecular Weight
495.54
References & Citations
[1]Dietrich JD, et al. Development of Orally Efficacious Allosteric Inhibitors of TNFα via Fragment-Based Drug Design. J Med Chem. 2021 Jan 14;64 (1) :417-429.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
![TIMM8A Mouse Monoclonal Antibody [Clone ID: OTI5C8]](https://cdn.genprice.uk/genprice/uk/genprice2.webp)
GTR15092448 1 Vial
Lentiviral human F2R shRNA (UAS) - Lentiviral human F2R shRNA (UAS, RFP) (100)
Ask
View Details