MRTX-1257
MRTX-1257 is a potent, selective, and irreversible covalent inhibitor of KRAS G12C. MRTX-1257 inhibits KRAS dependent ERK-phosphorylation in the H358 cell with IC₅₀ of 0.9 nM. Displays high selectivity for the Cys12 of KRAS G12C in NCI-H358 cells over other cysteines. Exhibits robust target engagement in vivo.
Product Specifications
Shipping Conditions
Gel Pack
Storage Conditions
-20ºC
Shelf Life
36 months
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