Velzatinib
Velzatinib (M4205) is a multi-target inhibitor for PDGFRB, PDGFRA, CSF1R, c-Kit, FLT3, and LCK, with an IC50s of 2.6, 50, 5.5, 44, 141 and 141 nM, respectively. Velzatinib exhibits antitumor efficacy in xenograft mouse models[1].
Product Specifications
CAS Number
2590556-80-0
Product Name Alternative
M4205; IDRX-42
UNSPSC
12352005
Target
C-Fms; c-Kit; FLT3; PDGFR; Src
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/m4205.html
Purity
99.47
Solubility
DMSO : 4 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CN1N=CC(C2=CC=C(CNC3=NC=NC(C4=CN=C5C=C(C=CN54)OCCCN6CCCC6)=C3)C=C2)=C1
Molecular Formula
C29H32N8O
Molecular Weight
508.62
References & Citations
[1]Blum A, et al. Identification of M4205─ A highly selective inhibitor of KIT mutations for treatment of unresectable metastatic or recurrent gastrointestinal stromal tumors[J]. Journal of Medicinal Chemistry, 2023, 66 (4) : 2386-2395.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
Lck; PDGFRα; PDGFRβ
Available Sizes
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