Velzatinib

Velzatinib (M4205) is a multi-target inhibitor for PDGFRB, PDGFRA, CSF1R, c-Kit, FLT3, and LCK, with an IC50s of 2.6, 50, 5.5, 44, 141 and 141 nM, respectively. Velzatinib exhibits antitumor efficacy in xenograft mouse models[1].

Product Specifications

CAS Number

[2590556-80-0]

Product Name Alternative

M4205; IDRX-42

UNSPSC

12352005

Target

C-Fms; c-Kit; FLT3; PDGFR; Src

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/m4205.html

Purity

99.47

Solubility

DMSO : 4 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CN1N=CC(C2=CC=C(CNC3=NC=NC(C4=CN=C5C=C(C=CN54)OCCCN6CCCC6)=C3)C=C2)=C1

Molecular Formula

C29H32N8O

Molecular Weight

508.62

References & Citations

[1]Blum A, et al. Identification of M4205─ A highly selective inhibitor of KIT mutations for treatment of unresectable metastatic or recurrent gastrointestinal stromal tumors[J]. Journal of Medicinal Chemistry, 2023, 66 (4) : 2386-2395.