GNE-495
GNE-495 is a potent and selective MAP4K4 inhibitor with an IC50 of 3.7 nM.
Product Specifications
CAS Number
[1449277-10-4]
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
MAP4K
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/GNE-495.html
Purity
99.49
Solubility
DMSO : 2.17 mg/mL (ultrasonic)
Smiles
O=C(C1=C2C=CC(C3=CC=CC(F)=C3)=NC2=C(N)N=C1)NC4CN(C(C5CC5)=O)C4
Molecular Formula
C22H20FN5O2
Molecular Weight
405.42
Precautions
H315, H319, H320
References & Citations
[1]Ndubaku CO et al. Structure-Based Design of GNE-495, a Potent and Selective MAP4K4 Inhibitor with Efficacy in Retinal Angiogenesis. ACS Med Chem Lett. 2015 Jun 29;6 (8) :913-8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MAP4K4/HGK
Available Sizes
Curated Selection
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