2′-Deoxy-β-L-uridine

2'-Deoxy-β-L-uridine is a nucledside analogue and a specific substrate for the viral enzyme, shows no stereospecificity against herpes simplex 1 (HSV1) thymidine kinase (TK) . 2′-Deoxy-β-L-uridine exerts antiviral activity via the interation of 5'-triphosphates with the viral DNA polymerase[1][2].

Product Specifications

CAS Number

[31501-19-6]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Nucleoside Antimetabolite/Analog

Type

Oligonucleotides

Related Pathways

Cell Cycle/DNA Damage

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/2-deoxy-β-l-uridine.html

Purity

99.96

Solubility

DMSO : 116.67 mg/mL (ultrasonic)

Smiles

O=C(NC(C=C1)=O)N1[C@@H]2C[C@@H](O)[C@H](CO)O2

Molecular Formula

C9H12N2O5

Molecular Weight

228.20

Precautions

H302, H315, H319, H335

References & Citations

[1]Spadari S, et al. L-thymidine is phosphorylated by herpes simplex virus type 1 thymidine kinase and inhibits viral growth. J Med Chem. 1992 Oct 30;35 (22) :4214-20. |[2]Lin TS, et al. Design and synthesis of 2',3'-dideoxy-2',3'-didehydro-beta-L-cytidine (beta-L-d4C) and 2',3'-dideoxy 2',3'-didehydro-beta-L-5-fluorocytidine (beta-L-Fd4C), two exceptionally potent inhibitors of human hepatitis B virus (HBV) and potent inhibitors of human immunodeficiency virus (HIV) in vitro. J Med Chem. 1996 Apr 26;39 (9) :1757-9.