TC-G-1008
TC-G-1008 (GPR39-C3) is a potent and orally available GPR39 agonist with EC50 values of 0.4 and 0.8 nM for rat and human receptors respectively.
Product Specifications
CAS Number
[1621175-65-2]
Product Name Alternative
GPR39-C3
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
GPR39
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/TC-G-1008.html
Purity
99.36
Solubility
DMSO : ≥ 100 mg/mL
Smiles
CS(=O)(NC1=CC=C(CNC2=NC(NC)=NC(C3=NC=CC=C3)=C2)C(Cl)=C1)=O
Molecular Formula
C18H19ClN6O2S
Molecular Weight
418.90
Precautions
H302, H315, H319, H335
References & Citations
[1]Peukert S, et al. Discovery of 2-Pyridylpyrimidines as the First Orally Bioavailable GPR39 Agonists. ACS Med Chem Lett. 2014 Aug 4;5 (10) :1114-8.|[2]Shimizu Y, et al. Rho kinase-dependent desensitization of GPR39; a unique mechanism of GPCR downregulation. Biochem Pharmacol. 2017 Sep 15;140:105-114.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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