Biotinylated Human Siglec-2 / CD22 Protein, Fc Tag, premium grade, ultra sensitivity (primary amine labeling)

B-cell receptor CD22 is also known as Sialic acid-binding Ig-like lectin 2 (Siglec-2), B-lymphocyte cell adhesion molecule (BL-CAM), T-cell surface antigen Leu-14, which belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. CD22 mediates B-cell B-cell interactions, and may be involved in the localization of B-cells in lymphoid tissues. Siglec-2 / CD22 binds sialylated glycoproteins, one of which is CD45. Siglec2 / CD22 plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 101.6 kDa. The protein migrates as 139 kDa±5 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

● -20°C to -70°C for 24 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Immobilized Monoclonal Anti-Human CD22 Antibody, Human IgG1 at 1 μg/mL (100 μL/well) can bind Biotinylated Human Siglec-2 Protein, Fc Tag, premium grade, primary amine labeling (Cat. No. CD2-H5254) with a linear range of 0.2-8 ng/mL (QC tested).