(±) 11 (12) -EET

(±) 11 (12) -EET is a NLRP3 inflammasome inhibitor. (±) 11 (12) -EET can be used for the research of anti-inflammatory, angiogenic and cardioprotective[1][2][3][4][6].

Product Specifications

CAS Number

[87173-81-7]

Product Name Alternative

11,12-EET

UNSPSC

12352005

Target

NOD-like Receptor (NLR)

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/racemic-11-12-eet.html

Concentration

312.04 μM * 250 μL in Ethanol

Purity

98.30

Solubility

10 mM in DMSO

Smiles

CCCCC/C=C\C[C@H]1O[C@H]1C/C=C\C/C=C\CCCC(O)=O

Molecular Formula

C20H32O3

Molecular Weight

320.47

References & Citations

[1] Luo XQ, et al. Epoxyeicosatrienoic acids inhibit the activation of NLRP3 inflammasome in murine macrophages. J Cell Physiol. 2020;235 (12) :9910-9921.|[2]Chacos N, et al. Novel epoxides formed during the liver cytochrome P-450 oxidation of arachidonic acid. Biochem Biophys Res Commun. 1982;104 (3) :916-922.|[3]Oliw EH, et al. Oxygenation of arachidonic acid by hepatic monooxygenases. Isolation and metabolism of four epoxide intermediates. J Biol Chem. 1982;257 (7) :3771-3781.|[4]Capdevila JH, et al. Cytochrome P450 and arachidonic acid bioactivation. Molecular and functional properties of the arachidonate monooxygenase. J Lipid Res. 2000;41 (2) :163-181.|[5]Wang Z, et al. Arachidonic acid inhibits basolateral K channels in the cortical collecting duct via cytochrome P-450 epoxygenase-dependent metabolic pathways. Am J Physiol Renal Physiol. 2008;294 (6) :F1441-F1447.|[6]Spector AA. Arachidonic acid cytochrome P450 epoxygenase pathway. J Lipid Res. 2009;50 Suppl (Suppl) :S52-S56.