TGFBR1-IN-2
Product Specifications
UNSPSC Description
TGFBR1-IN-2 (Compound AQA) is a TGFBR1 inhibitor and an antibacterial agent. TGFBR1-IN-2 is a substrate for cytochrome P450s. TGFBR1-IN-2 contains the pyridyl-6-methyl moiety necessary for Mycobacterium tuberculosis inhibition and has potent inhibitory activity against non-replicating and persistent Mycobacterium tuberculosis[1].
Target Antigen
Bacterial; Cytochrome P450; TGF-β Receptor
Type
Reference compound
Related Pathways
Anti-infection;Metabolic Enzyme/Protease;TGF-beta/Smad
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/tgfbr1-in-2.html
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC1=NC(C2=NC(NC3=CC=NC=C3)=C4C=CC=CC4=N2)=CC=C1
Molecular Weight
313.36
References & Citations
[1]Nandakumar, et al. Dual Inhibition of Mycobacterium tuberculosis and the Host TGFBR1 by an Anilinoquinazoline. Journal of medicinal chemistry. 2023, 66(21):14724-14734.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-164793/TGFBR1-IN-2-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-164793/
Clinical Information
No Development Reported
CAS Number
733806-89-8
Available Sizes
Curated Selection
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