TGFBR1-IN-2

TGFBR1-IN-2 (Compound AQA) is a TGFBR1 inhibitor and an antibacterial agent. TGFBR1-IN-2 is a substrate for cytochrome P450s. TGFBR1-IN-2 contains the pyridyl-6-methyl moiety necessary for Mycobacterium tuberculosis inhibition and has potent inhibitory activity against non-replicating and persistent Mycobacterium tuberculosis[1].

Product Specifications

CAS Number

[733806-89-8]

UNSPSC

12352005

Target

Bacterial; Cytochrome P450; TGF-β Receptor

Type

Reference compound

Related Pathways

Anti-infection; Metabolic Enzyme/Protease; TGF-beta/Smad

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/tgfbr1-in-2.html

Purity

98.88

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC1=NC(C2=NC(NC3=CC=NC=C3)=C4C=CC=CC4=N2)=CC=C1

Molecular Formula

C19H15N5

Molecular Weight

313.36

References & Citations

[1]Nandakumar, et al. Dual Inhibition of Mycobacterium tuberculosis and the Host TGFBR1 by an Anilinoquinazoline. Journal of medicinal chemistry. 2023, 66 (21) :14724-14734.