PAR-2 antagonist 1
PAR-2 antagonist 1 (Compound 9a) is a protease-activated receptor 2 (PAR2) antagonist with an IC50 value of 0.9 μM. PAR-2 antagonist 1 can effectively inhibit the proliferation and migration of breast cancer cells[1].
Product Specifications
CAS Number
313957-41-4
UNSPSC
12352211
Target
Protease Activated Receptor (PAR)
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/par-2-antagonist-1.html
Smiles
O=C(N/C(C(NCC1=CC=CC=C1)=O)=C\C2=CC=CC3=C2C=CC=C3)C4=CC=CC=C4
Molecular Formula
C27H22N2O2
Molecular Weight
406.48
References & Citations
[1]Kim T, et al. Discovery of Protease-activated receptor 2 antagonists derived from phenylalanine for the treatment of breast cancer. Bioorg Chem. 2024 Sep;150:107496.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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