MELK-8a (hydrochloride)
MELK-8a hydrochloride is a novel maternal embryonic leucine zipper kinase (MELK) inhibitor with an IC50 of 2 nM.
Product Specifications
CAS Number
2096992-20-8
Product Name Alternative
NVS-MELK8a (hydrochloride)
UNSPSC
12352005
Target
MELK
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/MELK-8a-hydrochloride.html
Purity
99.31
Solubility
DMSO : 8.6 mg/mL (ultrasonic; warming) |H2O : ≥ 100 mg/mL
Smiles
CN(CC1)CCN1C2=CC=C(N3C=C(C4=CC=NC=C4OCC5CCNCC5)C=N3)C=C2.Cl
Molecular Formula
C25H33ClN6O
Molecular Weight
469.02
References & Citations
[1]Touré BB, et al. Toward the Validation of Maternal Embryonic Leucine Zipper Kinase: Discovery, Optimization of Highly Potent and Selective Inhibitors, and Preliminary Biology Insight. J Med Chem. 2016 May 26;59 (10) :4711-23.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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