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MELK-8a (hydrochloride)

MELK-8a hydrochloride is a novel maternal embryonic leucine zipper kinase (MELK) inhibitor with an IC50 of 2 nM.

Product Specifications

CAS Number

[2096992-20-8]

Product Name Alternative

NVS-MELK8a (hydrochloride)

UNSPSC

12352005

Target

MELK

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/MELK-8a-hydrochloride.html

Purity

99.31

Solubility

DMSO : 8.6 mg/mL (ultrasonic; warming) |H2O : ≥ 100 mg/mL

Smiles

CN(CC1)CCN1C2=CC=C(N3C=C(C4=CC=NC=C4OCC5CCNCC5)C=N3)C=C2.Cl

Molecular Formula

C25H33ClN6O

Molecular Weight

469.02

References & Citations

[1]Touré BB, et al. Toward the Validation of Maternal Embryonic Leucine Zipper Kinase: Discovery, Optimization of Highly Potent and Selective Inhibitors, and Preliminary Biology Insight. J Med Chem. 2016 May 26;59 (10) :4711-23.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-100368A/MELK-8a-hydrochloride-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-100368A/MELK-8a-hydrochloride-SDS-MedChemExpress.pdf

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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