DCLK1-IN-5
DCLK1-IN-5 (Compound a24) is a DCLK1 inhibitor (IC50: 179.7 nM). DCLK1-IN-5 inhibits lipopolysaccharide -induced inflammation via inhibiting DCLK1-mediated IKKβ phosphorylation. DCLK1-IN-5 protects mice against inflammation-induced lung injury and sepsis[1].
Product Specifications
CAS Number
3028774-14-0
UNSPSC
12352005
Target
Ser/Thr Protease
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/dclk1-in-5.html
Solubility
10 mM in DMSO
Smiles
O=S(C1=C(NC2=NC(NC3=C(OC)C=C(NC(N4CCN(C)CC4)=S)C=C3)=NC=C2Cl)C=CC=C1)(C(C)C)=O
Molecular Formula
C26H32ClN7O3S2
Molecular Weight
590.16
References & Citations
[1]Cai B, et al. Discovery of a doublecortin-like kinase 1 inhibitor to prevent inflammatory responses in acute lung injury. Bioorg Chem. 2024 Apr;145:107215.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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