Guanine

Guanine is one of the fundamental components of nucleic acids (DNA and RNA) . Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds. Guanine has the potential to serve as a large-capacity N pool. Guanine has cytotoxic, antinociceptive and neuroprotective effects[1][2][3][4].

Product Specifications

CAS Number

[73-40-5]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

DNA/RNA Synthesis; Endogenous Metabolite

Type

Natural Products

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Guanine.html

Purity

98.0

Solubility

DMSO : 0.15 mg/mL (ultrasonic; warming) |H2O : < 0.1 mg/mL

Smiles

O=C1N=C(N)NC2=C1NC=N2

Molecular Formula

C5H5N5O

Molecular Weight

151.13

Precautions

H315, H319, H335

References & Citations

[1]Mojzeš P, et al. Guanine, a high-capacity and rapid-turnover nitrogen reserve in microalgal cells. Proc Natl Acad Sci U S A. 2020 Dec 22;117 (51) :32722-32730. |[2]Chauhan V, et al. In Silico Discovery and Validation of Amide Based Small Molecule Targeting the Enzymatic Site of Shiga Toxin. J Med Chem. 2016 Dec 8;59 (23) :10763-10773. |[3]Messina E, et al. Guanine nucleotide depletion triggers cell cycle arrest and apoptosis in human neuroblastoma cell lines. Int J Cancer. 2004 Mar 1;108 (6) :812-7.|[4]de Oliveira ED, et al. Mechanisms involved in the antinociception induced by spinal administration of inosine or guanine in mice. Eur J Pharmacol. 2016 Feb 5;772:71-82.