Docosanoic acid

Docosanoic acid (Behenic acid) is a long-chain saturated fatty acid. Docosanoic acid inhibits the double-stranded DNA (dsDNA) binding activity of p53 DNA binding domain, with a Kd of 12 nM. Docosanoic acid has low bioavailability and can increase cholesterol in humans[1][2][3].

Product Specifications

CAS Number

[112-85-6]

Product Name Alternative

Behenic acid

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

DNA/RNA Synthesis; Endogenous Metabolite

Type

Natural Products

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/Docosanoic_acid.html

Purity

99.40

Solubility

DMF : 9.09 mg/mL (ultrasonic; warming; heat to 60°C) |DMSO : 1 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : < 0.1 mg/mL

Smiles

CCCCCCCCCCCCCCCCCCCCCC(O)=O

Molecular Formula

C22H44O2

Molecular Weight

340.59

Precautions

H302, H315, H319, H335

References & Citations

[1]Cater NB, et al. Behenic acid is a cholesterol-raising saturated fatty acid in humans. Am J Clin Nutr. 2001 Jan;73 (1) :41-4.|[2]Moreira DK, et al. Evaluation of structured lipids with behenic acid in the prevention of obesity. Food Res Int. 2017 May;95:52-58. |[3]Iijima H, et al. The inhibitory action of long-chain fatty acids on the DNA binding activity of p53. Lipids. 2006 Jun;41 (6) :521-7.