Oclacitinib (monomaleate)
Oclacitinib maleate (PF-03394197 maleate) is a novel JAK inhibitor. Oclacitinib maleate (PF-03394197 maleate) is most potent at inhibiting JAK1 (IC50=10 nM) .
Product Specifications
CAS Number
1640292-55-2
Product Name Alternative
PF-03394197 (monomaleate)
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
JAK
Type
Reference compound
Related Pathways
Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/oclacitinib-monomaleate.html
Purity
99.87
Solubility
DMSO : 250 mg/mL (ultrasonic) |H2O : 25 mg/mL (ultrasonic)
Smiles
O=S(C[C@H]1CC[C@H](N(C)C2=C3C(NC=C3)=NC=N2)CC1)(NC)=O.O=C(O)/C=C\C(O)=O
Molecular Formula
C19H27N5O6S
Molecular Weight
453.51
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
JAK1; JAK2; JAK3; Tyk2
Citation 01
Dev Comp Immunol. 2018 Dec:89:44-53.|Virulence. 2024 Dec;15 (1) :2435372.|bioRxiv. 2025 February 21.|Mol Ther Oncol. 2025 Feb 3;33 (1) :200946.
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