PSN-GK1
PSN-GK1 is a potent glucokinase activator with an EC50 of 0.13 μM.
Product Specifications
CAS Number
745051-61-0
UNSPSC
12352005
Target
Glucokinase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/2H-Pyran-4-propanamide,__alpha_-[4-_cyclopropylsulfonyl_phenyl]-N-_5-fluoro-2-thiazolyl_tetrahydro-,___alpha_R_-.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=NC=C(F)S1)[C@@H](C2=CC=C(S(=O)(C3CC3)=O)C=C2)CC4CCOCC4
Molecular Formula
C20H23FN2O4S2
Molecular Weight
438.54
References & Citations
[1]Bertram LS, et al. SAR, pharmacokinetics, safety, and efficacy of glucokinase activating 2- (4-sulfonylphenyl) -N-thiazol-2-ylacetamides: discovery of PSN-GK1. J Med Chem. 2008 Jul 24;51 (14) :4340-5.|[2]Fyfe MC, et al. Glucokinase activator PSN-GK1 displays enhanced antihyperglycaemic and insulinotropic actions. Diabetologia. 2007 Jun;50 (6) :1277-87.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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