JAK3-IN-7
JAK3-IN-7 is a potent and selective JAK3 inhibitor extracted from patent WO2011013785A1, has an IC50 of <0.01 μM.
Product Specifications
CAS Number
[1263774-57-7]
UNSPSC
12352005
Target
JAK
Type
Reference compound
Related Pathways
Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/1,6-Diazaspiro[3.5]nonane-1-propanenitrile,_3-methyl-_beta_-oxo-6-_7H-pyrrolo[2,3-d]pyrimidin-4-yl_-.html
Solubility
10 mM in DMSO
Smiles
N#CCC(N1CC(C)C12CN(C3=C4C(NC=C4)=NC=N3)CCC2)=O
Molecular Formula
C17H20N6O
Molecular Weight
324.38
References & Citations
[1]NOJI, Satoru, et al. NITROGEN-CONTAINING SPIRO-RING COMPOUND AND MEDICINAL USE OF SAME. WO2011013785A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
JAK3
Available Sizes
Curated Selection
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