What is the catalog number for CI-949?

The catalog number for CI-949 is HY-U00364.

What sizes are available for CI-949?

CI-949 is available in the following size(s): 1 Each.

CI-949 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures CI-949?

CI-949 is manufactured by QuantiMol.

What is the estimated delivery time for CI-949?

Estimated delivery time for CI-949 is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for CI-949?

The safety data sheet for CI-949 is available here: http://file.medchemexpress.com/batch_PDF/HY-U00364/.

CI-949

CI-949 is an allergic mediator release inhibitor, which inhibits histamine, leukotriene C4/D4 (LTC4/LTD4), and thromboxane B2 (TXB2) release with IC50s of 11.4 μM, 0.5 μM and 0.1 μM, respectively.

Product Specifications

CAS Number

104961-19-5

UNSPSC

12352005

Target

Histamine Receptor; Leukotriene Receptor; Prostaglandin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Inflammation/Immunology; Endocrinology

Assay Protocol

https://www.medchemexpress.com/1H-Indole-2-carboxamide,_5-methoxy-3-_1-methylethoxy_-1-phenyl-N-2H-tetrazol-5-yl-.html

Solubility

10 mM in DMSO

Smiles

O=C(C(N1C2=CC=CC=C2)=C(OC(C)C)C3=C1C=CC(OC)=C3)NC4=NN=NN4

Molecular Formula

C20H20N6O3

Molecular Weight

392.41

References & Citations

[1]Conroy MC, et al. Inhibition of histamine, leukotriene C4/D4, and thromboxane B2 release from human leukocytes and human chopped lung mast cells by the allergic mediator release inhibitor, CI-949. J Allergy Clin Immunol. 1990 Dec;86 (6 Pt 1) :902-8.|[2]Adolphson RL, et al. CI-949: a new, potential antiallergy compound inhibits antigen-induced allergic reactions in guinea-pigs in vitro and in vivo. Pulm Pharmacol. 1990;3 (4) :203-8.