LTD4 antagonist 1

LTD4 antagonist 1 is a potent, orally active antagonist of leukotriene D4 (LTD4) with a Ki of 0.57 nM.

Product Specifications

CAS Number

[136564-67-5]

UNSPSC

12352005

Target

Leukotriene Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/1H-Indole-5-carboxamide,_3-[[2-methoxy-4-[[[_2-methylphenyl_sulfonyl]amino]carbonyl]phenyl]methyl]-1-methyl-N-_4,4,4-trifluoro-2-methylbutyl_-.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=CC2=C(N(C)C=C2CC3=CC=C(C(NS(=O)(C4=CC=CC=C4C)=O)=O)C=C3OC)C=C1)NCC(C)CC(F)(F)F

Molecular Formula

C31H32F3N3O5S

Molecular Weight

615.66

References & Citations

[1]Robert T. Jacobs, et al. Synthesis, Structure-Activity Relationships, and Pharmacological Evaluation of a Series of Fluorinated 3-Benzyl-5-Indolecarboxamides: Identification of 4-[[5-[ ((2R) -2-Methyl-4,4,4-trifluorobutyl) carbamoyl]-1-methylindol-3-yl]methyl]-3methoxy-N-[ (2-methylphenyl) sulfonyl]benzamide, a Potent, Orally Active Antagonist of Leukotrienes D4 and E4. Journal of Medicinal Chemistry (1994), 37 (9), 1282-97.