LTD4 antagonist 1
LTD4 antagonist 1 is a potent, orally active antagonist of leukotriene D4 (LTD4) with a Ki of 0.57 nM.
Product Specifications
CAS Number
136564-67-5
UNSPSC
12352005
Target
Leukotriene Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/1H-Indole-5-carboxamide,_3-[[2-methoxy-4-[[[_2-methylphenyl_sulfonyl]amino]carbonyl]phenyl]methyl]-1-methyl-N-_4,4,4-trifluoro-2-methylbutyl_-.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC2=C(N(C)C=C2CC3=CC=C(C(NS(=O)(C4=CC=CC=C4C)=O)=O)C=C3OC)C=C1)NCC(C)CC(F)(F)F
Molecular Formula
C31H32F3N3O5S
Molecular Weight
615.66
References & Citations
[1]Robert T. Jacobs, et al. Synthesis, Structure-Activity Relationships, and Pharmacological Evaluation of a Series of Fluorinated 3-Benzyl-5-Indolecarboxamides: Identification of 4-[[5-[ ((2R) -2-Methyl-4,4,4-trifluorobutyl) carbamoyl]-1-methylindol-3-yl]methyl]-3methoxy-N-[ (2-methylphenyl) sulfonyl]benzamide, a Potent, Orally Active Antagonist of Leukotrienes D4 and E4. Journal of Medicinal Chemistry (1994), 37 (9), 1282-97.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
LTD4/CysLT1
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