COX/5-LO-IN-1
COX/5-LO-IN-1 (Atreleuton analog) is an inhibitor of cylooxygenase (COX) and lipoxygenase 5-LOX , used for the research of inflammatory and allergic disease states.
Product Specifications
CAS Number
154355-75-6
Product Name Alternative
Atreleuton analog
UNSPSC
12352005
Target
COX; Lipoxygenase
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Urea,_N-[3-[5-[_4-fluorophenyl_methyl]-2-thienyl]-1-methyl-2-propyn-1-yl]-N-hydroxy-.html
Solubility
10 mM in DMSO
Smiles
O=C(N)N(C(C)C#CC1=CC=C(CC2=CC=C(F)C=C2)S1)O
Molecular Formula
C16H15FN2O2S
Molecular Weight
318.37
References & Citations
[1]Lipoxygenase and cyclooxygenase inhibiting compounds. US 5516789 A|[2]Brooks CD, et al. (R) - (+) -N-[3-[5-[ (4-fluorophenyl) methyl]-2-thienyl]-1-methyl- 2-propynyl]-N-hydroxyurea (ABT-761), a second-generation 5-lipoxygenase inhibitor. J Med Chem. 1995 Nov 24;38 (24) :4768-75.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-LOX; COX
Frequently Asked Questions
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