COX/5-LO-IN-1

COX/5-LO-IN-1 (Atreleuton analog) is an inhibitor of cylooxygenase (COX) and lipoxygenase 5-LOX , used for the research of inflammatory and allergic disease states.

Product Specifications

CAS Number

[154355-75-6]

Product Name Alternative

Atreleuton analog

UNSPSC

12352005

Target

COX; Lipoxygenase

Type

Reference compound

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Urea,_N-[3-[5-[_4-fluorophenyl_methyl]-2-thienyl]-1-methyl-2-propyn-1-yl]-N-hydroxy-.html

Solubility

10 mM in DMSO

Smiles

O=C(N)N(C(C)C#CC1=CC=C(CC2=CC=C(F)C=C2)S1)O

Molecular Formula

C16H15FN2O2S

Molecular Weight

318.37

References & Citations

[1]Lipoxygenase and cyclooxygenase inhibiting compounds. US 5516789 A|[2]Brooks CD, et al. (R) - (+) -N-[3-[5-[ (4-fluorophenyl) methyl]-2-thienyl]-1-methyl- 2-propynyl]-N-hydroxyurea (ABT-761), a second-generation 5-lipoxygenase inhibitor. J Med Chem. 1995 Nov 24;38 (24) :4768-75.