PI3Kα/mTOR-IN-1

PI3Kα/mTOR-IN-1 is a potent PI3Kα/mTOR dual inhibitor, with an IC50 of 7 nM for PI3Kα in a cell assay, and Kis of 10.6 nM and 12.5 nM for mTOR and PI3Kα in a cell free assay , respectively.

Product Specifications

CAS Number

[1013098-90-2]

UNSPSC

12352005

Target

MTOR; PI3K

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Pyrido[2,3-d]pyrimidin-7_8H_-one,_2-amino-8-cyclopentyl-4-methyl-6-_1H-pyrazol-4-yl_-.html

Purity

99.30

Solubility

10 mM in DMSO

Smiles

O=C1C(C2=CNN=C2)=CC3=C(C)N=C(N)N=C3N1C4CCCC4

Molecular Formula

C16H18N6O

Molecular Weight

310.35

References & Citations

[1]Le PT, et al. Design and synthesis of a novel pyrrolidinyl pyrido pyrimidinone derivative as a potent inhibitor of PI3Kα and mTOR. Bioorg Med Chem Lett. 2012 Aug 1;22 (15) :5098-103.