5-HT3 antagonist 3

5-HT3 antagonist 3 (Compound 15b) is a high-affinity 5-HT3 receptor antagonist. 5-HT3 antagonist 3 binds to 5-HT3 receptors in rat brain cortical membranes with Ki of 0.25 nM[1].

Product Specifications

CAS Number

120635-47-4

UNSPSC

12352005

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/4H-Pyrido[3,2,1-jk]carbazol-11_8H_-one,_5,6,9,10-tetrahydro-10-[_2-methyl-1H-imidazol-1-yl_methyl]-.html

Solubility

10 mM in DMSO

Smiles

O=C1C(CN2C=CN=C2C)CCC(N3CCC4)=C1C5=C3C4=CC=C5

Molecular Formula

C20H21N3O

Molecular Weight

319.40

References & Citations

[1]van Wijngaarden I, et al. Development of high-affinity 5-HT3 receptor antagonists. Structure-affinity relationships of novel 1,7-annelated indole derivatives. J Med Chem. 1993 Nov 12;36 (23) :3693-9.