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AE0047 Hydrochloride

AE0047 Hydrochloride is a calcium blocker, used in the research of hypertensive disease.

Product Specifications

CAS Number

116308-56-6

UNSPSC

12352005

Target

Calcium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Watanipidine_monohydrochloride.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=C(C)NC(C)=C(C(OC)=O)C1C2=CC(N(=O)=O)=CC=C2)OCCC3=CC=C(N4CCN(C(C5=CC=CC=C5)C6=CC=CC=C6)CC4)C=C3.Cl

Molecular Formula

C41H43ClN4O6

Molecular Weight

723.26

References & Citations

[1]Ashimori A, et al. Novel 1,4-dihydropyridine calcium antagonists. II. Synthesis and antihypertensive activity of 3-[4- (substituted amino) phenylalkyl]ester derivatives. Chem Pharm Bull (Tokyo) . 1991 Jan;39 (1) :91-9.|[2]Ashimori A, et al. Synthesis and pharmacological effects of optically active 2-[4- (4-benzhydryl-1-piperazinyl) phenyl]-ethyl methyl 1,4-dihydro-2,6-dimethyl-4- (3-nitrophenyl) -3,5-pyridinedicarboxylate hydrochloride. Chem Pharm Bull (Tokyo) . 1991 Jan;39 (1) :108-11.|[3]Yamanaga K, et al. AE0047-mediated calcium channel blocking in vascular smooth muscles. Gen Pharmacol. 1997 Sep;29 (3) :337-43.|[4]Nishikawa M, et al. Protection against endothelial abnormalities by a novel calcium channel blocker, AE0047, in stroke-prone spontaneously hypertensive rats. Gen Pharmacol. 1999 Mar;32 (3) :299-305.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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